Isolation and characterization of two new cytotoxic glycosylsphingolipids from the stem bark of Pithecellobium eriorhachis Harms. (Fabaceae)

Abstract

= 4.78 ± 0.56 μg/mL). Pithecellobioside B (2) is identified as a potent cytotoxic compound that warrants further investigation for the development of novel antiproliferative drugs targeting LN229 epithelial-like glioblastoma cells. These findings indicate that Pithecellobiosides A and B (1-2) represent new cerebrosides with selective cytotoxicity against glioblastoma cells, highlighting P. eriorachis as a promising source of bioactive glycosphingolipids.