Investigating the Clinical Implications and Prevalence of Distributive Frequency of Secretor and Non-Secretor Status of ABH Antigenic Substances as a Novel Risk Factor in Ectopic Pregnancy: A Systematic Review and Meta-Analysis of the Allele-Type Analysis from Published Studies.

Abstract

Ectopic pregnancy is a life-threatening condition that affects millions of women worldwide. Recent studies have hypothesized or suggested that the distributive frequency of secretor and non-secretor status of ABH antigenic substances may be a novel risk factor for ectopic pregnancy. However, the research community, healthcare providers and practitioners deserve to have the clarity of this information which are not readily available. The current study was aimed at investigating the imperative role and prevalence of distributive frequency of secretor and non-secretor status of ABH antigenic substances as a novel risk factor in ectopic pregnancy. A systematic review of 400 articles out of 500 were conducted using powerful search engines and databases which includeviz:- PubMed, Scopus, Web of Science, and Google Scholar, Science Direct, IEEE Xplore, JSTOR, EBSCOhost, ProQuest and Semantic Scholar. The results of this systematic review have shown that the distributive frequency of secretor and non-secretor status of ABH antigenic substances were significantly associated with the risk of ectopic pregnancy. This systematic review havealso provided strong evidence that the distributive frequency of secretor and non-secretor status of ABH antigenic substances can now be considered as a novel risk factor for ectopic pregnancy.