article · Genes

Integrative Genomic and in Silico Analysis Reveals Mitochondrially Encoded Cytochrome C Oxidase III (MT—CO3) Overexpression and Potential Neem-Derived Inhibitors in Breast Cancer

Oluwaseun E. Agboola
Abimbola Fadugba
Basiru Olaitan Ajiboye
Samuel S. Agboola
Folake O. Olojo
Oluwatoyin Mary Oyinloye
Oluranti E. Olaiya
Esther Y. Omolayo
Zainab A. Ayinla
Foluso O. Osunsanmi
Babatunji Emmanuel Oyinloye

20257 citationsOpen accessFederal University Oye-Ekiti

Abstract

Connecting traditional medicine with current genomics and computational biology, this work proposes a methodology for structure-guided drug design and development using neem-derived chemicals and finds MT-CO3 as a potential therapeutic target for breast cancer.

Research topics

Computational Drug Discovery Methods
Pharmacogenetics and Drug Metabolism
Plant biochemistry and biosynthesis

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.3390/genes16050546

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