article · OpenNano
Microfluidic systems enable precise control of fluid movement through micro-channel networks, offering alternatives to conventional pharmaceutical methods. This review covers microfabrication and mixing mechanisms, detailing their implementation in manufacturing drug delivery vehicles such as liposomes, microparticles, nanoparticles, and nano-in-microparticle formulations. It examines several analytical microfluidic configurations, including lab-on-a-chip platforms, dielectrophoresis, droplet microfluidics, and digital microfluidics. Particular emphasis is placed on pharmaceutical applications for antibody screening techniques and cell-free protein synthesis systems. Furthermore, the review discusses modular approaches to designing and constructing custom-made microfluidic setups. Overall, these microfluidic technologies demonstrate significant utility across healthcare domains, presenting practical opportunities for biosensors, point-of-care diagnostics, continuous health monitoring, and patient care management.
Conventional pharmaceutical manufacturing and analytical testing can be rigid and resource-intensive. Microfluidic devices provide precise, miniaturised control over chemical and biological fluids. By improving the production of advanced drug delivery carriers and facilitating rapid analytical testing, these technologies support the development of decentralised point-of-care diagnostic tools, more responsive patient care management, and novel biomanufacturing techniques like cell-free protein synthesis.
The review identifies applications for pharmaceutical manufacturers and diagnostic developers, specifically in formulating drug carriers such as nanoparticles and liposomes, antibody screening, and point-of-care diagnostic devices. Because the abstract describes an overview of methodologies, analytical platforms, and futuristic custom modular approaches, the work represents an early-stage conceptual and review framework rather than an applied, near-market commercial product.
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Microfluidics are systems that set forth valuable means to efficiently control fluid movement and dynamics in specially fabricated micro-channel systems. The advancement of the unique design and microfluidics technology can offer an alternative to the traditional systems used in many pharmaceutical applications. In this context, this review presents a vivid depiction of microfluidics and an overview of the various mixing techniques and mechanisms. Insights on how microfluidic methodologies can be utilized in the efficient manufacture of various drug delivery systems e.g., liposomes, microparticles, nanoparticles, and nano-in-microparticles are provided. Moreover, the different analytical applications of microfluidic systems such as lab-on-chip, dielectrophoresis, droplet microfluidic, and digital microfluidics are addressed. Specifically, the pharmaceutical approaches for antibody screening technology and Cell-free protein synthesis system are highlighted. Lastly, the modular microfluidic approach in planning and constructing microfluidic systems is explored as a key player for implementing futuristic custom-made microfluidic systems. Collectively, microfluidic systems hold the potential in various domains including biosensors, point-of-care diagnostics, health monitoring and patient care management.
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DOI: 10.1016/j.onano.2023.100156
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