article · European Polymer Journal
Scaffolds play a critical role in bone tissue engineering by providing a structural framework that supports cell growth and differentiation necessary for tissue repair. To function effectively, these structures must satisfy key biological requirements, including biocompatibility, biodegradability, and appropriate mechanical strength. Recent developments focus on various advanced additive manufacturing methods to produce three-dimensional scaffolds tailored for bone regeneration. These techniques include stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, and bioprinting variants such as laser-based, inkjet, and extrusion approaches. Alongside manufacturing methods, careful material selection is essential to overcome common limitations associated with conventional bone grafts. A comprehensive understanding of design principles and performance trade-offs remains vital for evaluating how scaffolds can be integrated successfully into tissue engineering applications.
Bone tissue regeneration requires structures that safely integrate with the body and assist natural healing. By evaluating diverse 3D fabrication methods and material properties, this work clarifies how engineered scaffolds can be better designed to mimic natural bone, potentially reducing reliance on traditional bone grafts.
The work addresses bone graft alternatives and regenerative medicine solutions for biomedical manufacturers and clinical researchers. Because it reviews fabrication methods, including multiple additive manufacturing and bioprinting techniques, without presenting a newly validated product, the insights primarily guide early-stage to intermediate research and development rather than immediate clinical use.
AI-generated from the published abstract. Always read the original work before citing.
Meeting the escalating demands in biomedical applications has spurred the creation of diverse scaffolds, where the selection of materials and manufacturing techniques stands as a linchpin in fostering bone tissue formation. These scaffolds provide a fundamental structural framework that supports cell growth and differentiation. It is vital for tissue repair, addressing various biological requisites such as biocompatibility, biodegradability, and mechanical properties becomes imperative. This comprehensive review discusses recent advancements in the techniques for manufacturing 3D scaffolds tailored specifically for bone tissue engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, and bioprinting (including laser-based, inkjet and extrusion 3D bioprinting) are meticulously explored. Focusing on their respective applications, limitations, as well as advantages and disadvantages within the context of bone tissue regeneration. Furthermore, the article underscores the pivotal role of material selection as a potential solution to address challenges associated with bone grafts. It emphasizes the need for a nuanced understanding of the significant considerations regardless of the tissue type when designing or evaluating the suitability of scaffolds for integration into the expansive realm of tissue engineering.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1016/j.eurpolymj.2024.113251
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
