article · Evidence-based Complementary and Alternative Medicine
Hagenia abyssinica is a plant found in the highlands of Ethiopia, where its flowers have long been used in traditional medicine to treat wounds. This study examined the wound healing and anti-inflammatory properties of an eighty percent methanol crude flower extract using rodent models. The extract and its solvent fractions were formulated into topical ointments and tested in excision and incision wound models, while anti-inflammatory action was tested against carrageenan-induced paw swelling. Both five percent and ten percent crude extract ointments significantly accelerated wound contraction from the fourth day and increased tissue tensile strength compared to negative controls. Aqueous and ethyl acetate fractions also showed high wound contraction rates. Furthermore, oral doses of the extract significantly inhibited paw inflammation, confirming that the flowers possess genuine wound healing and anti-inflammatory effects.
Traditional herbal remedies frequently lack experimental confirmation despite widespread community use. Confirming that flower extracts of Hagenia abyssinica promote tissue repair and reduce inflammation in animal models validates traditional healthcare practices. This evidence provides a solid foundation for researchers exploring alternative, plant-derived therapies for wound management and acute inflammation.
The findings could ultimately inform the development of botanical wound-care ointments and anti-inflammatory products by pharmaceutical or natural medicine developers. However, because the evidence is restricted to early-stage laboratory studies in mice and rats, the research is at a very early stage. Substantial further work, including identification of active compounds, standardisation of extracts, and human clinical trials, is required before commercial application is feasible.
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Background . Hagenia abyssinica (Bruce) J.F. Gmel (Rosaceae) is distributed in the highlands of Ethiopia. The flowers of Hagenia abyssinica (Bruce) J.F. Gmel are used traditionally to treat wound. However, there was no scientific report on wound healing activity of Hagenia abyssinica (Bruce) J.F. Gmel. Thus, this study was initiated to investigate the wound healing and anti‐inflammatory activities of 80% methanol crude extract of flowers of Hagenia abyssinica in mice. Objective . The objective of this study was to evaluate the wound healing and anti‐inflammatory activity of 80% methanol crude flower extract of Hagenia abyssinica in mice. Methods . Air‐dried flowers of Hagenia abyssinica were grounded and macerated three times successively by 80% methanol. The dried extract was fractionated with chloroform, ethyl acetate, and water. Phytochemical screening tests were performed according to established procedures. The crude extract and solvent fractions were formulated as ointments. Wound healing activity of the crude extract was evaluated using excision and incision wound models, and the wound healing activities of solvent fractions were evaluated by using the excision wound model. The anti‐inflammatory activity of the 80% methanol extract of Hagenia abyssinica was evaluated using carrageenan‐induced hind paw edema model in mice. Result . The 2000 mg/kg test dose of the 10% (w/w) crude extract ointment was safe in rats. Both the 5% (w/w) and 10% (w/w) crude extract ointment‐treated groups showed significant wound contraction starting from the day 4 th . Both 5% (w/w) and 10% (w/w) crude extract ointments showed significant ( P < 0.001) increment of tensile strength compared to the negative control. The 10% (w/w) aqueous and ethyl acetate fraction ointment revealed high ( P < 0.001) percentage of wound contraction. The 100 mg/kg, 200 mg/kg, and 400 mg/kg oral administration of the crude extract had significant inhibition of the paw edema in mice of carrageenan‐induced inflammation. Conclusion . The results of this study evidenced that both 5% w/w and 10% w/w 80% methanol extract ointment of the flowers of Hagenia abyssinica have wound healing and anti‐inflammatory effects.
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DOI: 10.1155/2020/9645792
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