article · Applied Microbiology and Biotechnology

In vitro and in vivo synergistic effects of cyclizine and piroxicam in combination with linezolid against methicillin-resistant Staphylococcus aureus

2026Open accessMansoura University

Abstract

optrA gene was detected in four linezolid S. aureus-resistant isolates (LRSA) Linezolid/cyclizine and linezolid/piroxicam synergism was detected against LRSA. Combinations revealed complete lung protection in lung-infected LRSA murine model.

Research topics

Antimicrobial Resistance in Staphylococcus
Phenothiazines and Benzothiazines Synthesis and Activities
Tuberculosis Research and Epidemiology

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DOI: 10.1007/s00253-026-13738-9

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