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article · Pharmaceuticals

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II

20245 citationsOpen accessHelwan University

Abstract

Compounds <b>7c</b> and <b>8b</b> hold promise as potential anticancer drugs due to their anti-proliferative and proapoptotic effects, which are mediated by their action on the topoisomerase enzyme, particularly Topo II.

Research topics

  • Cancer therapeutics and mechanisms
  • Synthesis and bioactivity of alkaloids
  • Synthesis and biological activity

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DOI: 10.3390/ph17111487

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