article · Frontiers in Immunology

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda

Phillip Ssekamatte
Bernard S. Bagaya
Reinout van Crevel
Davis Kibirige
David Patrick Kateete
Stephen Cose
Obondo James Sande
Diana Sitenda
Andrew Peter Kyazze
Marjorie Nakibuule
Rose Nabatanzi
Irene Andia Biraro

20246 citationsOpen accessMakerere University

Abstract

Type 2 DM impairs the memory phenotypes and functional profiles of Mtb-specific CD4+ and CD8+ T cells, potentially indicating underlying immunopathology towards increased active TB disease risk.

Research topics

Tuberculosis Research and Epidemiology
Mycobacterium research and diagnosis
Immunodeficiency and Autoimmune Disorders

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3389/fimmu.2024.1480739

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