article · The Journal of Clinical Endocrinology & Metabolism

Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Kidney Disease Disrupts 11-Oxygenated Androgen Biosynthesis

Maria Tomkins
Wiebke Arlt
Marie McIlroy
Peter Conlon
Rowan Hardy
Jacky L. Snoep
Angela E. Taylor
Lorna C Gilligan
Mark Sherlock
Karl‐Heinz Storbeck
Lorraine Harper
Conall M. O’Seaghdha
Tara McDonnell
Fozia Shaheen
Michael Sagmeister
Declan de Freitas
Leanne Cussen
Imken Oestlund
Colm Magee
Mark Denton
Michael O’Reilly

20244 citationsOpen accessStellenbosch University

Abstract

This is the first in vivo study to confirm a central role for renal HSD11B2 in 11-oxygenated androgen biosynthesis. Determining the clinical implications of this observation for patients with CKD requires further research.

Research topics

Hormonal Regulation and Hypertension
Hormonal and reproductive studies
Sexual Differentiation and Disorders

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1210/clinem/dgae714

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