Impact of Serum Albumin & Pre-albumin as well as Anthropometric Measurements on Long Term Survival Outcomes after Allogeneic Stem Cell Transplantation

Abstract

Abstract Background Allogeneic HSCT is the treatment of choice for treatment of patients with high risk features of acute leukemia or those who are relapsed after standard treatment. By now, there are few studies on nutritional assessment of hematological patients before and after HSCT, and additionally, most rely on one single assessment method. Objective Evaluating nutritional indicators as well as anthropometric measurements in long term survivors post-transplant, identifying their relationship on transplant outcomes. Methods The present work included 30 patients with two or more years after allogeneic stem cell transplantation who were following up at Bone Marrow Transplantation Unit, Ain Shams University Hospitals, during the Jan-2019 till Jan- 2023. We assessed nutritional lab parameters including albumin, prealbumin as well as anthropometric measurements including BMI, waist, circumference, waist hip ratio and body fat percentage using bioelectric impendence in long term survivors as well as assessment of quality of life using FACT-BMT questionnaire. Results We found statistically significant association between nutritional lab parameters as well as anthropometric measurements with late transplant outcome including incidence of chronic GVHD, disease relapse and transplant related mortality as well as post-transplant quality of life. Conclusion Nutritional lab biomarkers and anthropometric measurements in long term survivors post-allogeneic stem cell transplantation were a low cost, non- invasive biomarkers for early and late transplant complications, patients’ survival and quality of life.