article · BMC Research Notes
A cross-sectional investigation at Ho Teaching Hospital evaluated the effects of red blood cell transfusions on 102 hospitalised patients with varying illness severities. Most participants presented with severe or moderate conditions. Laboratory testing pre- and post-transfusion demonstrated statistically significant increases in key haematological markers, including haemoglobin levels, red blood cell counts, haematocrit percentages, and platelet counts. In addition, patient clinical outcomes evaluated 24 hours after the procedure showed a significant relationship with the baseline severity of their diagnosed conditions. Overall, incorporating red blood cell transfusions into medical care delivered positive haematological and clinical benefits. These findings suggest that decisions regarding blood transfusions require comprehensive pre-treatment assessments that account for specific laboratory indices, physical examinations, and underlying diagnostic severity to optimise patient outcomes.
Blood transfusions are critical medical interventions, but uncertainty remains regarding their optimal application in clinical settings. Demonstrating that red blood cell therapy reliably improves haematological counts while showing that overall recovery is tied to initial illness severity helps clinicians refine treatment protocols. This supports better clinical decision-making, ensuring that scarce blood supplies are administered effectively to the patients most likely to benefit.
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Blood transfusion is a vital healthcare therapy and lifesaving procedure, yet research on its effects has shown mixed results, with some studies in Ghana questioning its appropriate use. This study aimed to assess the clinical and hematological effects of red blood cell transfusion at Ho Teaching Hospital. In a cross-sectional design, clinical and demographic data were obtained from electronic records of 102 consenting patients prescribed transfusion. Hematological data were collected by analyzing pre- and post-transfusion blood samples, while clinical outcomes were documented 24 h post-transfusion. A total of 102 patients participated in this research. The severities of participants’ conditions were categorized as mild (2.9%), moderate (32.4%), severe (55.9%), and critical (8.8%). The changes in the means of Hb (1.03 g/dl), RBC (0.37 × 1012/L), hematocrit (3.05%) and platelets (26.87 × 109/l) were significantly associated with the blood transfusion ( p < 0.05). Also, the clinical outcomes were significantly related to the severity of the conditions ( p < 0.05). The study concluded that, the use of transfusion as part of treatment yielded positive outcomes both clinically and hematologically. The severity of the diagnosed conditions also affected the clinical outcomes. Subsequently, assessments for transfusion should consider the hematological parameters, clinical examination and other factors related to the patient's diagnosis.
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DOI: 10.1186/s13104-026-07966-5
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