IMPACT OF CONCURRENT CHEMORADIOTHERAPY ON QUALITY OF LIFE AND MOOD IN PATIENTS WITH LARYNGEAL CANCER

Abstract

Introduction: Laryngeal cancer, often treated with radiotherapy and chemotherapy, Although chemoradiotherapy is effective for treating laryngeal cancer, it can significantly affect patients' quality of life (QoL). This study aimed to describe the impact of chemoradiotherapy on the quality of life and mood of patients with laryngeal cancer. Methods: A retrospective study involving 127 patients with Tis-T3 laryngeal cancer assessed QoL and depressive symptoms before treatment, and at 6 and 12 months post-treatment using validated questionnaires (EORTC QLQ-C30, H&N35, CES-D). Results: Physical functioning and head and neck-specific symptoms worsened at 6 months, but most improved by 12 months, except for taste/smell, dry mouth, and sticky saliva. Emotional functioning and mood improved over time despite physical deterioration . Conclusion: Concurrent chemoradiotherapy leads to temporary QoL deterioration, followed by gradual recovery and improved emotional wellbeing, highlighting the importance of long-term psychological support.