article · AIDS

Impact of antiretroviral therapy during acute or early HIV infection on virologic and immunologic outcomes: results from a multinational clinical trial

Trevor A. Crowell
Sonya L. Heath
Sharon A. Riddler
Joseph Puleo
Asma Naqvi
Joseph J. Eron
Beatriz Grinsztejn
Gert U. van Zyl
Susan J. Little
Roberto C. Arduino
John W. Mellors
Scott F. Sieg
Brian Clagett
Susan E. Cohn
James F. Rooney
Joshua C. Cyktor
Jintanat Ananworanich
Robert W. Coombs
Lawrence Fox
Javier R. Lama
Justin Ritz
Lu Zheng
Cecilia Kanyama
Ann C. Collier
Pornphen Tantivitayakul
Eric S. Daar

202415 citationsOpen accessStellenbosch University

Abstract

Earlier ART initiation during AEHI reduced but did not eliminate the persistence of HIV-infected cells in blood. These findings explain the rapid viral rebound observed after ART cessation in early-treated individuals with undetectable HIV DNA by less sensitive methods.

Research topics

HIV Research and Treatment
HIV/AIDS Research and Interventions
HIV/AIDS drug development and treatment

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1097/qad.0000000000003881

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