article · Frontiers in Immunology

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape

Nicky de Vrij
Kurt Boonen
Kassa Mekibib
Tigist Mekonnen
Ilse Maes
Seid Getahun Abdela
G Coukos
Fentaw Bialfew
Saskia van Henten
Bart Cuypers
Elise Pepermans
Yetemwork Aleka
Thibaut Vanbaelen
Thao‐Thy Pham
Mezgebu Silamsaw Asres
Kris Laukens
Feleke Tilahun Zewdu
Mikias Woldetensay
Seid Hassen
Lauren Thijs
Louise Laurijssen
Geert Baggerman
Malgorzata Anna Domagalska
Kadrie Ramadan
Wim Adriaensen

2026Open accessGondar University

Abstract

This first comprehensive map of the <i>Leishmania</i> immunopeptidome in human disease reveals conserved and prevalent antigens that can inform rational vaccine design and deepen our understanding of protective T cell responses in leishmaniasis.

Research topics

Research on Leishmaniasis Studies
vaccines and immunoinformatics approaches
Monoclonal and Polyclonal Antibodies Research

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DOI: 10.3389/fimmu.2026.1765843

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