Hypnosis to improve life quality in invasive mole: A case report

Abstract

Gestational trophoblastic tumors (GTTs) encompass a spectrum of neoplastic conditions, including invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Invasive mole, which frequently develops following a complete hydatidiform mole, represents the most common form. A cancer diagnosis constitutes a profoundly destabilizing experience, often resulting in considerable psychological distress. Moreover, while chemotherapy remains the cornerstone of treatment, it is frequently associated with adverse effects that compromise both quality of life and psychological well-being. In this context, clinical hypnosis has recently emerged as a promising complementary therapy to mitigate such symptoms. We report the case of a patient with invasive mole who received five clinical hypnosis sessions over 8 weeks, in conjunction with standard chemotherapy. Symptom evolution was assessed using the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index (PSQI), and the SF-12 Health Survey. Pain levels were monitored using a 0-10 numerical rating scale. The patient demonstrated marked improvements: Quality of Life Index increased from 29 to 41, pain intensity decreased from 7 to 2, and PSQI scores showed significant improvement in sleep quality. This case highlights the potential of clinical hypnosis as a supportive intervention in the management of gestational trophoblastic tumors. By modulating psychological and physiological responses, hypnosis contributed to improved symptom control and enhanced treatment tolerance. These findings support a more holistic cancer care model, although further controlled studies are needed to validate these outcomes.