Human Wharton-Jelly- Mesenchymal Stem Cells Microvesicles And Exosomes As Potential Antiviral Activity Against Herpes Simplex Type 2

Abstract

The human herpes simplex virus type 2 (HSV-2) is one of the most common viruses in humans, causing severe genital ulceration and is linked to HIV transmission [26]. HSV-2 is a large, double-stranded DNA (dsDNA) that is classified as a member of the subfamily Alpha Herpesviridae [35]. Intimate contact is the most prevalent mode of transmission; HSV-2 is primarily transmitted sexually. HSVs were primarily associated with orolabial ulceration in the past, but more recently, changes in the epidemiology of HSV-2 have been described, including an increase in genital infections [24]. There is a dearth of knowledge regarding the factors that influence virulence, particularly the significance of the genetic makeup of certain isolates and the absence of effective therapeutic agents, necessitating further investigation. Emphasise the need for proper treatment to limit the spread of the virus and slow the progression of the disease. Consequently, the majority of studies on HSV-2 have focused on treatment resistance, vaccine development, seroprevalence, and antiviral development [3,6,11,14,44].