review · Human Vaccines & Immunotherapeutics
A systematic review and meta-analysis of electronic biomedical databases assessed human papillomavirus (HPV) vaccination rates and determinant factors among adolescent schoolgirls across sub-Saharan Africa. The findings demonstrate that overall vaccine uptake remains low, with an estimated pooled prevalence of 28.53 percent. Uptake rates varied widely across the region, reaching a high of 62.52 percent in Kenya and falling to 3.77 percent in Nigeria. Having good knowledge of the vaccine and maintaining a positive attitude towards it were significantly associated with higher uptake. To counter these low coverage rates, targeted community education, structured awareness initiatives, and school-based immunisation programmes are required to encourage vaccination and improve protection across adolescent populations.
HPV vaccination is essential for preventing HPV-related health conditions, yet regional uptake remains critically low. By synthesising data on coverage rates and key behavioural determinants, this work provides clear guidance for public health bodies, schools, and communities to design effective educational programmes and delivery strategies that address vaccine hesitancy and safeguard the health of adolescent girls.
The abstract does not indicate a direct commercialisation pathway, as the study focuses on epidemiological meta-analysis. However, the findings provide actionable evidence for health authorities, non-governmental organisations, and public health programme planners to design applied school-based immunisation drives and community health education initiatives across the region.
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Despite the ongoing global vaccination campaign aimed at preventing human papillomavirus (HPV) related health issues, the uptake of the HPV vaccine remains unacceptably low in developing regions, particularly in sub-Saharan Africa (SSA). Therefore, this systematic review and meta-analysis aimed at determining the pooled prevalence and associated factors of HPV vaccine uptake among adolescent school girls in SSA. Electronic bio-medical databases were explored. Pooled prevalence, publication bias, meta-regression, sub-group, and sensitivity analysis were performed. The estimated pooled prevalence of HPV vaccine uptake was 28.53% [95% CI: (5.25, 51.81)]. Having good knowledge and a positive attitude was significantly associated with HPV vaccine uptake in SSA. Subgroup analysis revealed the highest uptake was 62.52% from Kenya and the lowest was 3.77% in Nigeria. The HPV vaccine uptake is low. It underscores the need for community education, school-based immunization, and education programs that promote the uptake of the vaccine to increase coverage.
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DOI: 10.1080/21645515.2024.2326295
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