article · Alzheimer s & Dementia

Heterogeneity in the Genetic Architecture of Alzheimer disease (AD) across Ancestry Groups

Penelope Benchek
Nicholas R. Ray
R. Mayeux
Jiji T. Kurup
G W Beecham
Sven‐Thorsten Dietrich
Sterling C. Johnson
Adam C Naj
Li‐San Wang
Giuseppe Tosto
Margaret Pericak‐Vance
Rufus O. Akinyemi
Lindsay A. Farrer
Christiane Reitz
Kara L Hamilton‐Nelson
Jonathan L Haines
Goldie S Byrd
Jeffery M Vance
Bush Wh

2025Open accessUniversity of Ibadan

Abstract

While AD pathobiology is consistent across affected individuals, the effects of genetic variation may differ greatly across ancestry groups. Our estimates show a low to modest shared genetic component of AD risk across ancestry groups, however these are likely underestimates of real effects. These findings highlight that ancestry-specific genetic contributors for AD remain to be identified.

Research topics

Genetic Associations and Epidemiology
Alzheimer's disease research and treatments
Dementia and Cognitive Impairment Research

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DOI: 10.1002/alz70855_107285

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