article · Journal of drug targeting
PURPOSE: This study investigates the development and evaluation of rosuvastatin-loaded polymeric nanoparticles as a targeted wound-healing therapy. The work aims to overcome solubility and bioavailability limitations and to enhance therapeutic outcomes in cutaneous wound repair. METHODS: release study was assessed. A gel incorporated optimised formulation was evaluated in a rat excisional wound model. Wound-area reduction and healing percentages were quantified over 14 days. RESULTS: < .001). CONCLUSIONS: The findings demonstrate that polymeric nanoprecipitation offers a versatile platform to tailor nanoparticle characteristics and release profiles, translating into marked improvements in wound repair. This approach holds promise for the clinical translation of statin-based nanoformulations in both acute and chronic wound management.
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DOI: 10.1080/1061186x.2025.2549579
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