article · Zenodo (CERN European Organization for Nuclear Research)

Guiding Principles for Pragmatic Randomized Trials of Tuberculosis Regimens

Patrick Phillips
Samuel G. Schumacher
C S G Cousins
Susan Dorman
Francesca Conradie
G Davies
Cara Cassino
Gustavo E. Velásquez
M Hoelscher
Andrew Vernon
Derek Sloan
Gavin Churchyard
Payam Nahid
Aparna Anderson
Hanif Esmail
Karen Sanders
Salome Charalambous
Katherine Fielding
Carole D. Mitnick
Jodie A. Schildkraut
David McNeeley
Christian Lienhardt

2026Open accessUniversity of the Witwatersrand

Abstract

Investment in tuberculosis research has led to the development of efficacious new treatments. Pragmatic trials are needed to evaluate the effectiveness of new treatments in real-life routine practice conditions and thereby appropriately inform practice guidelines and facilitate uptake. Leveraging the expertise of the FAST-TB (Facilitating Accelerated Science and Translation for TB Regimen Development) network, this review lays out a scientific framework and guiding principles for pragmatic TB trials.

Research topics

Tuberculosis Research and Epidemiology
Diagnosis and treatment of tuberculosis
Infectious Diseases and Tuberculosis

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DOI: 10.5281/zenodo.20229181

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