article · Foods
This study investigated how ginger water affects body weight and energy expenditure in rats, specifically by examining its impact on gene expression related to carbohydrate and lipid metabolism. Ginger water, a liquid obtained during the freeze-drying of fresh ginger rhizomes, was found to contain chrysin and galangin. When administered to rats, it significantly reduced body weight gain, total cholesterol, and serum triacylglycerol levels. The research also observed changes at the genetic level, with ginger water downregulating genes associated with fat storage and upregulating genes involved in fat burning and glucose transport. These findings suggest that ginger water helps reduce body weight gain by influencing the transcription of proteins involved in energy metabolism.
Obesity is a major global health concern linked to many serious diseases. This research identifies ginger water as a potential natural intervention that could help manage body weight and improve energy metabolism. Understanding its mechanisms at the genetic level could pave the way for new strategies to combat obesity.
This early-stage research, conducted in rats, suggests ginger water could be explored as a natural ingredient for weight management or dietary supplements. Potential users might include individuals seeking natural approaches to support metabolic health. Further research is needed to confirm these effects in humans and to develop specific applications, as this study is foundational and not yet near-market.
AI-generated from the published abstract. Always read the original work before citing.
Obesity is a serious global problem that causes predisposition to numerous serious diseases. The current study aims to investigate the effect of ginger water on body weight and energy expenditure through modulation of mRNA expression of carbohydrate and lipid metabolism. A white colored liquid obtained during freeze-drying of fresh rhizomes of <i>Zingiber officinal</i> was collected and named ginger water. It was used to treat rats, then blood and tissue samples were collected from the liver and white adipose at the end of the experiment. The serum was prepared and used for biochemical assays, while tissue samples were used for RNA isolation and gene expression analysis via Reverse transcription polymerase chain reaction (RT-PCR). Results of High Performance Liquid Chromatography (HPLC) analysis of ginger water revealed the presence of chrysin and galangin at concentrations of 0.24 µg/mL and 0.53 µg/mL, respectively. Average body weight gain decreased significantly in groups that received ginger water. In addition, both total cholesterol and serum triacylglycerol were reduced in the groups that received ginger water. Furthermore, mRNA expression of Sterol regulatory element-binding protein 1 (SREBP-1c) in the liver and leptin in adipose tissues were downregulated, while those of adiponectin, hepatic carnitine palmitoyltransferase1 (CPT-1), acyl-coA oxidase (ACO), Glucose transporter 2 (GLUT-2), and pyruvate kinase (PK) were upregulated in ginger water-treated groups. These results clearly revealed the lowering body weight gain effect of ginger water, which most likely occurs at the transcriptional level of energy metabolizing proteins.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/foods9010038
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
