article · Journal of the Egyptian Society of Parasitology
Herbal remedies have been studied as alternative or adjuvant treatment options against parasitic infections.Treating trichinellosis with albendazole (ABZ) showed many drawbacks despite its efficacy.This study assessed the effectiveness of genistein (Soybean extract), either with or without ABZ, intreating experimental murine trichinellosis and evaluated the regulatory mechanisms. One hundredSwiss albino laboratory-bred mice were categorized into five groups: G1 uninfected and untreatedmice, G2 infected untreated mice, G3 infected and ABZ treated, G4; infected and genistein treated, G5infected and ABZ &genistein treated. Each group was divided according to the scarification time (7-or 40-days post-infection (dpi), respectively). The treatment efficacy was evaluated parasitological,histopathological, immunological, immunohistochemical (GATA3, glutathione peroxidase 1 (GPX1),and caspase 3) methods and by SEM. Combination of genistein & ABZ in treating trichinellosis showedthe best drug efficacy, with reduction of adults and larvae count at 96.73% & 81.56 %, respectively.They showed the highest degree in amelioration of histopathological changes and reduction of inflammationparallel to genistein-treated ones with significant reduction of GATA3 & caspase 3 expressions,but significant elevation of GPX1 expression as well as highest degeneration of adults and larvaeby SEM.
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DOI: 10.21608/jesp.2024.351356
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