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article · Drug and Chemical Toxicology

Gastroprotective mechanism of <i>Talinum triangulare</i> on ethanol-induced gastric ulcer in Wistar rats <i>via</i> inflammatory, antioxidant, and H <sup>+</sup> /K <sup>+</sup> -ATPase inhibition-mediated pathways

20242 citationsOsun State University

Abstract

, thereby alleviating progression of lipid peroxidation cascades. Also, AETT exhibited mitigating effect on ethanol-induced oxidative harm by enhancing the functionality of protective enzymes and elevating glutathione (GSH) concentration. Overall, AETT exhibited enhancements in activities of cytoprotective antioxidant enzymes, mitigated impact of oxidative stress and inflammation, inhibited lipid peroxidation, and decreased UI score. These beneficial effects could be attributed to phytochemicals present in AETT including 6,10,14-trimethyl-2-pentadecanone and Phytol. Outcome of this study established the traditional herbal claims of AETT.

Research topics

  • Helicobacter pylori-related gastroenterology studies
  • Pharmacological Effects of Natural Compounds
  • Natural Antidiabetic Agents Studies

Sustainable Development Goals

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DOI: 10.1080/01480545.2024.2365435

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