article · Antioxidants
Leaf extract from Albizia anthelmintica exhibits significant gastroprotective effects in animal models with indomethacin-induced gastric ulcers. Pretreatment of rats with doses of 100 and 200 mg per kg prevented gastric lesions by 87.4 percent and 92.3 percent respectively, avoiding structural damage to the gastric mucosa. The extract suppresses inflammatory and oxidative markers, significantly lowering elevated levels of IKK-beta, NF-kappa-B, TNF-alpha, IL-6, iNOS, and lipid peroxidation. Concurrently, it increases reduced levels of glutathione peroxidase activity and restores reduced glutathione. The protective performance of the leaf extract closely matches the effects observed with famotidine, a standard anti-ulcer medication. These therapeutic outcomes appear to stem from the natural anti-inflammatory and antioxidant activities present within the plant phytoconstituents, demonstrating the potential of the extract for gastric ulcer management.
Gastric ulcers caused by anti-inflammatory drugs represent a frequent and debilitating medical issue. Identifying plant-based alternatives that match the efficacy of existing pharmaceutical drugs offers new possibilities for safer therapies. This research demonstrates that a natural leaf extract can protect the stomach lining through combined anti-inflammatory and antioxidant actions, matching the performance of a conventional anti-ulcer medication in animal tests.
This research could support pharmaceutical or nutraceutical developers seeking natural candidates for gastric ulcer prevention and treatment. The evidence is currently at an early preclinical stage, based entirely on animal trials and computational insights. Significant further work, including toxicological validation, formulation standardisation, and human clinical trials, is required before any commercial anti-ulcer product or therapeutic formulation can be developed for patients.
AI-generated from the published abstract. Always read the original work before citing.
We have previously reported that the leaf extract of <i>Albizia anthelmintica</i> exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg<sup>-1</sup>) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, <i>Albizia anthelmintica</i> is a potential candidate for management of gastric ulcers with antioxidant properties.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/antiox10020176
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
