Frequency of KRAS and BRAF mutations in colorectal carcinoma and their association with clinical-pathological characteristics in a tertiary hospital in Kenya

Abstract

Colorectal carcinoma in our patients is more common in males and tend to occur at a younger age. The patients tend to have a high tumor pathological stage and nodal involvement at diagnosis. The high frequency of <i>KRAS</i> exon 2,3,4 mutation and low frequency <i>of BRAF V600E</i> mutations is similar to what has been reported in literature.