article · RSC Advances
= 0.384 for pH 5, 7.4, respectively. The nanoplatform has a selectivity index of 8.44 and a 9-fold increase in cytotoxicity upon light activation for MDA-MB-231 cells. The nanoplatform MSNCDs-FA@TMPyP generated 41.12% early apoptosis, 22.07% late apoptosis, and 5.31% primary necrosis in MDA-MB-231 breast cancer cells upon light activation. This research presents a promising new bifunctional nanocomposite that combines the benefits of targeted chemotherapy and photodynamic therapy, offering a synergistic approach to cancer treatment that could lead to improved outcomes.
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DOI: 10.1039/d5ra10048h
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