article · European Journal of Medicinal Chemistry Reports
l-Arginine is an essential amino acid involved in diverse physiological processes. It functions as a precursor for nitric oxide, a molecule that possesses powerful antioxidant and anti-inflammatory properties. Through mediated nitric oxide production, l-arginine actively neutralises free radicals and decreases cellular oxidative stress. A broad examination of published literature highlights its therapeutic relevance across numerous human conditions, including cardiovascular diseases, neurodegenerative illnesses, metabolic disorders, and immune system performance, alongside general anti-ageing effects. It also contributes to enhanced endothelial function. While l-arginine shows clear promise as a natural agent for mitigating and preventing diverse health conditions, additional research is required to fully outline its exact physiological mechanisms and establish effective, condition-specific dosing strategies.
Oxidative stress and chronic inflammation are central factors in many widespread illnesses, from heart disease to cognitive decline. Clarifying how a common amino acid like l-arginine produces protective nitric oxide could inform preventative healthcare approaches, aiding the development of evidence-based interventions that support cardiovascular health, immune defences, and healthy ageing.
The findings could eventually inform preventative nutraceuticals, clinical dietary supplements, or adjunct therapies targeting cardiovascular, metabolic, or neurodegenerative disorders. The intended users include clinical researchers, healthcare providers, and wellness product developers. Because the work is an exploratory literature review that stresses the need to identify optimal dosing and underlying mechanisms, real-world commercial translation remains at an early stage.
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l-Arginine is an essential amino acid that plays a crucial role in various physiological processes. It serves as a precursor for nitric oxide (NO), which has potent antioxidant and anti-inflammatory properties. This review aims to comprehensively examine the medicinal importance of l-arginine as a natural antioxidant in preventing human health disorders. A comprehensive literature search was conducted using PubMed, Google Scholar, and other databases. Studies investigating the antioxidant effects of l-arginine and its potential role in preventing various diseases were included. l-Arginine has been shown to mediate NO production with strong antioxidant properties, scavenging free radicals and reducing oxidative stress. It has demonstrated therapeutic potential in preventing and mitigating various health conditions, including: Cardiovascular diseases, Neurodegenerative diseases, Metabolic disorders, Immune function and Anti-aging effects. l-Arginine is a potent natural antioxidant with significant medicinal importance. Its ability to scavenge free radicals, improve endothelial function, and support immune function makes it a promising therapeutic agent for preventing and treating a wide range of human health disorders. Further research is warranted to fully elucidate the mechanisms of action and optimal dosage for specific conditions.
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DOI: 10.1016/j.ejmcr.2024.100175
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