Exploring the Association between Frequency Distribution of Secretor Status of ABH Antigenic Substances in Sickle Cell Traits and Sickle Cell Disease: A Systematic Review of Individual Data-based Meta-analysis of Published Literatures

Abstract

Background:The association between the frequency distribution of secretor and non-secretor status of ABH antigenic substances among sickle cell traits and sickle cell disease are not well documented and understood by many in the research community and this may be due to paucity of knowledge on this subject.Objective: The aim of the study is to systematically review and analyse all searched and extracted articles with citations from the individual data-bases/websites that have published literatures relating to the association between frequency distribution of secretor status of ABH antigenic substances among sickle cell traits and sickle cell disease population.Methods: A comprehensive literature search was conducted using multiple data-based published literatures on various websites and data bases such as PubMed, Scopus, and Web of Science databases.The search strategy included studies that have been investigated with keywords related to the relationship or association between "the frequency distribution of secretor status of ABH antigenic substances" and "sickle cell trait" and "sickle cell disease individuals".To achieve this a total of 250 studies were included in the review and 150 articles met the inclusion criteria and ten search engines were used for searching and extracting these articles.Results: The result of the systematic review shows that frequency distribution of secretor and nonsecretor status of ABH antigenic substances varied significantly with sickle cell trait and sickle cell disease as found in individual articles.Conclusion: This systematic review suggests that there may be a significant relationship or association between the frequency distribution of secretion and non-secretor status of ABH antigenic substances and sickle cell traits and sickle cell disease state.Further studies may be needed to confirm these findings.