article · Pharmacological Research - Modern Chinese Medicine
Diets high in fat and fructose are linked to obesity, diabetes, and cardiovascular issues. This research examined the effects of Aloe vera supplementation on mice fed a high-fat and high-fructose diet over a ten-week period. Twenty mice were divided into four dietary groups: a regular diet, a high-fat and fructose diet, and the same diet supplemented with either ten percent or twenty percent Aloe vera. Mice receiving the supplemented diets displayed significantly lower cholesterol levels than the unsupplemented high-fat and fructose group. Aloe vera supplementation significantly improved albumin levels alongside the activities of key antioxidant enzymes, specifically superoxide dismutase and catalase. Furthermore, while the high-fat and fructose diet elevated liver enzyme levels, examination of liver tissues from mice given the twenty percent Aloe vera supplement showed normal liver cell structures.
Diets rich in fat and fructose are major contributors to metabolic conditions like obesity and cardiovascular disease. Demonstrating that a common plant extract like Aloe vera can mitigate dietary oxidative stress, improve lipid balance, and protect liver structure offers valuable insights into potential nutritional strategies for managing metabolic disorders.
This work points toward potential applications in functional foods and dietary supplements aimed at managing metabolic disorders and dyslipidemia. Potential users include nutraceutical manufacturers and food scientists developing preventative health products. However, as an animal study conducted on mice over ten weeks, this research is at an early experimental stage and requires substantial further investigation before translation into commercial human products.
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Fat-rich diets are believed to induce obesity and contribute to the development of diabetes and cardiovascular disease in contrast high fructose diet was reported to increase gut surface area and enhance nutrient uptake resulting in weight gain. The study investigated the role of Aloe vera supplementation on oxidative stress, lipid profiles, and liver histology in high fat and fructose diet-fed mice. Twenty mice were distributed into four groups (n = 5). The groups received a regular diet, high fat and fructose diet (HFFD), HFFD plus 10% Aloe vera (HFFD+AV1), and HFFD plus 20% Aloe vera (HFFD+AV2) respectively, for 10 weeks. Lipid profile and liver function were evaluated from the serum, antioxidant activities were evaluated from liver homogenate while the liver was processed for light microscopy. The cholesterol level of HFFD+AV treated mice was significantly lower compared to HFFD treated mice. The alanine aminotransferase (ALT) level was significantly increased in HFFD-treated mice relative to the control. Aloe vera significantly improves albumin level plus superoxide dismutase and catalase activities of HFFD treated mice. The liver tissues of control and HFFD+AV2 treated mice showed normal hepatocytes. The study suggests that Aloe vera supplementation could prevent HFFD-induced oxidative stress and dyslipidemia. These findings might be used for further research on food supplementation to control metabolic disorders.
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DOI: 10.1016/j.prmcm.2022.100150
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