Exploring serum Dipeptidyl peptidase-4 levels: Associations with diabetes, glucose control and peripheral artery disease

Abstract

Objectives Elevated serum Dipeptidyl peptidase-4 (DPP4) levels have emerged as a potential diagnostic biomarker for diabetes. This study aimed to investigate the association between serum DPP4 levels and diabetes, explore potential pathophysiological mechanisms and assess the clinical implications. Material and Methods Serum DPP4 levels were measured in participants, and their diabetes status was determined. Statistical analysis was employed to evaluate associations between DPP4 levels and diabetes, as well as their impact on glycaemic control and potential implications for diabetes management. Results Elevated serum DPP4 levels were significantly associated with diabetes. Higher DPP4 levels correlated with poorer glucose control. Notably, individuals with diabetes and peripheral arterial disease (PAD) exhibited markedly elevated DPP4 levels, suggesting a link between DPP4 and PAD in diabetes. Conclusion Serum DPP4 levels hold promise as a diagnostic tool for identifying diabetes and assessing its severity. This finding raises questions about the role of DPP4 in glucose metabolism and vascular complications. Further research may unveil mechanisms and therapeutic opportunities, potentially enhancing personalised diabetes care and preventive strategies for PAD in diabetic populations.