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article · Biological Psychiatry Cognitive Neuroscience and Neuroimaging

Executive function in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium

Abstract

In the first mega-analysis of fMRI studies of executive function in OCD, we found strong evidence of weaker frontoparietal activation during executive function tasks. Our findings also suggest a failure of default mode network regions to appropriately disengage during task performance in OCD.

Research topics

  • Obsessive-Compulsive Spectrum Disorders
  • Personality Disorders and Psychopathology
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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DOI: 10.1016/j.bpsc.2026.02.007

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