Evaluation of the antioxidant activity and study of the acute toxicity of extracts from the leaves of Turraea heterophylla Sm. (Meliaceae) from Côte d'Ivoire

Abstract

This research work is based on the evaluation of the antioxidant activity and the study of the toxicity of various Turraea heterophylla leaf extracts. The antioxidant activity, carried out by spectrophotometry using the DPPH and ABTS methods, shows that the leaves of T. heterophylla have a significant capacity to reduce free radicals compared with those of the reference molecules (ascorbic acid and Trolox). The oral toxicity study using OECD method 423 justifies that T. heterophylla leaves can be considered as almost non-toxic with an LD50 greater than 5000 mg/kg BW. Taken together, the results obtained show that T. heterophylla leaves can be used to treat diseases associated with oxidative stress, while presenting no major danger to the body.