article · Biomedicine
Natural alternatives to non-steroidal anti-inflammatory drugs are sought to avoid unwanted side effects linked to synthetic treatments. Slime from the snail Helix aspersa Müller was examined through laboratory experiments, animal trials, and computational docking to assess its anti-inflammatory and antioxidant capabilities. In laboratory assays, the secretion exhibited dose-dependent anti-inflammatory action, preventing protein denaturation by up to 90.41 percent at 500 micrograms per millilitre and matching reference drugs in membrane stabilisation, antiprotease, and antilipoxygenase effects. In a rat ear swelling model, the same concentration reduced swelling by 76.68 percent, surpassing the performance of diclofenac whilst lessening oxidative stress. Molecular docking confirmed that constituents in the slime bind strongly to key inflammatory targets, evidencing a multimodal mechanism of action for managing inflammatory and oxidative conditions.
Conventional non-steroidal anti-inflammatory drugs frequently cause adverse side effects, spurring interest in safer substitutes. Demonstrating that Helix aspersa Müller slime can match or exceed standard drugs in reducing swelling and oxidative stress provides scientific grounding for a traditional remedy. This opens possibilities for designing natural therapies to manage inflammatory disorders through multiple biological targets.
The findings could inform the development of natural therapeutic alternatives to synthetic anti-inflammatory drugs for pharmaceutical and healthcare developers. Because the work is currently at an early testing stage encompassing computational, laboratory, and rodent models, substantial safety profiling, active constituent extraction, and clinical trials would be required before any commercial formulation or therapeutic deployment could be realised.
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Background: The search for effective natural alternatives to synthetic non-steroidal antiinflammatory drugs (NSAIDs), which are often associated with undesirable side effects, is an important axis of current research. The slime of the snail Helix aspersa Müller, is a traditional remedy that deserves scientific investigation for its potential therapeutic properties. Purpose: This study aimed to comprehensively evaluate the anti-inflammatory effects of Helix aspersa Müller slime using a combination of in vitro, in vivo, and in silico methodologies. Methods: In vitro analyses included assays for inhibition of protein denaturation, antiprotease and antilipoxygenase activities, and membrane stabilization, with diclofenac and indomethacin as reference standards. The in vivo component involved a rat model of auricular edema to measure the reduction of swelling and attenuation of oxidative stress. Molecular docking simulations were conducted to analyze the binding affinity of slime constituents for key inflammatory targets. Results: The slime exhibited potent, dose-dependent anti-inflammatory activity. In vitro, it inhibited protein denaturation by up to 90.41% at 500 µg/mL, with antiprotease, antilipoxygenase, and membrane-stabilizing effects comparable to standard drugs. In vivo, it reduced auricular edema in rats by 76.68% at a dose of 500 µg/mL, exceeding the efficacy of diclofenac and reducing oxidative stress. Molecular docking confirmed strong binding affinities with key inflammatory receptors, delineating a multimodal mechanism of action. Conclusion: The secretion of H. aspersa Müller demonstrates exceptional anti-inflammatory and antioxidant properties, validating its potential as a viable natural alternative to conventional NSAIDs for the management of inflammatory conditions and oxidative stress-related disorders.
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DOI: 10.37796/2211-8039.1714
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