article · Natural Product Research
The phytochemical profile of the hydro-methanolic extract from <i>Pistacia lentiscus</i> L. leaves (MEPLL) was analysed using the LC-ESI-MS/MS method, which identified 17 compounds. The major compounds identified were quinic acid (234.25 mg/g extract), tannic acid (45.92 mg/g extract), quercitrin (2.99 mg/g extract), protocatechuic acid (1.96 mg/g extract), and gallic acid (1.34 mg/g extract). MEPLL exhibited the most potent antioxidant activity, with IC<sub>50</sub> values of 4.79 ± 0.31 µg/mL for DPPH, 2.80 ± 0.02 µg/mL for ABTS, and an A<sub>0.5</sub> value of 3.80 ± 0.64 µg/mL for the phenanthroline assay. Additionally, MEPLL exhibited significant inhibitory effects against acetylcholinesterase (AChE) (IC<sub>50</sub> = 5.76 ± 0.97 µg/mL), butyrylcholinesterase (BChE) (IC<sub>50</sub> = 28.94 ± 1.48 µg/mL), and α-amylase (IC<sub>50</sub> = 8.9 ± 0.14 µg/mL), outperforming the positive controls. Molecular docking studies further supported these <i>in vitro</i> results.
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DOI: 10.1080/14786419.2025.2471836
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