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article · World Allergy Organization Journal

Evaluation of drug causality in SJS/TEN: The role of the lymphocyte transformation test and conventional/modified IFN-γ ELISpot assays

2026Open accessAin Shams University

Abstract

The Modified IFN-γ ELISpot assay outperformed the LTT and Conventional IFN-γ ELISpot in detecting drug-induced immune responses in SJS/TEN patients, particularly for high-risk drugs such as carbamazepine and sulphamethoxazole. Its superior sensitivity and reliability suggest it its role in identifying the culprit drugs in these patients.

Research topics

  • Drug-Induced Adverse Reactions
  • Contact Dermatitis and Allergies
  • Biosimilars and Bioanalytical Methods

Sustainable Development Goals

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DOI: 10.1016/j.waojou.2026.101344

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