Evaluation of Acute Toxicity, Antidepressant, Antioxidant Activities and Memory Ability of Curcuma longa Methanolic Extract in High fructose-treated rat

Abstract

Obesity is currently a public health problem due to its worryingly increasing prevalence over the last ten years.This disorder affects the behavior.The goal of the current study was to evaluate the effects of Curcuma longa methanolic extract and losartan on anxiety-and depression-like behaviors induced by a high fructose diet (HFD) in adult female Wistar rats.In this study, 2-monthold female Wistar rats aged between 74 and 100g were randomly divided into 6 groups as follows: four groups will be fed the HFD and another 2 groups will receive the standard diet.An evaluation by behavioral tests, depression and anxiety-like, was carried out by using Open field Test (OFT), Elevated Plus Maze test (EPM) and Forced Swim Test (FST).The results show that HFD administration significantly reduced the TCA in female rats when compared with standard diet-treated rats (-85%; p < 0.001).However, HFD + Curc administration significantly increased the TCA (+221%; p < 0.05), in comparison with the HFD group.The findings show also that HFD induced anxiety-like behavior and that the female rats a spent less TOA, compared with the control animals (-61%; p < 0.01).However, following Curc or Los administration, TOA was non significantly elevated in females (+110% and +71%, respectively), in comparison with HFD group (p > 0.05).HFD is associated with anxiety-like and depressive behaviors in adult female Wistar rats.Moreover, our results suggest that treatments with Curc and/or Los could serve as potential therapeutic agents for anxiety and depression induced by HFD.