EP18.31: Impact of increased nuchal translucency values on pregnancy outcomes

Abstract

To assess the adverse outcomes in pregnancies with increased nuchal translucency (NT). Retrospective, longitudinal study, carried out over 3 years period. Singleton pregnancies with NT values above 99th percentile and complete information about the delivery were investigated. Included pregnancies were divided into 3 groups: group 1 (NT = 2,6-3,5 mm), group 2 (NT = 3,5-4,5 mm) and group 3 (NT≥4,5 mm). Demographic features, clinical characteristics, structural/chromosomal anomaly rates and perinatal outcomes were compared. SPSS programme was used to analyse the data. Maternal age, gravidity, parity and Crown–rump length at the time of NT measurement did not differ significantly between group 1, 2 and 3. Normal ultrasonographic anatomy was found in 48.3%, 13.4%, and 9.2% of groups 1, 2, and 3, respectively (p⟨0,05). Group 3 had the lowest normal karyotype rate (39.2%) (p⟨0,05). Miscarriage and therapeutic terminations of pregnancy were more frequent in group 3 compared to group 1 (8.9% vs. 4.9% and 66.1% vs. 32.7%, respectively) (p⟨0,05). The highest rate of abnormal postnatal anatomic findings was found in group 3 (73.2%) (p⟨0,05). NT values above 99th percentile for gestational age seem to be associated with increased rates of chromosomal/structural abnormalities and adverse perinatal outcomes.