review · Advanced Healthcare Materials
Recent advances in resorbable polymeric biomaterials encompass diverse geometrical designs, varied resorption mechanisms, and wide biomedical utility. Engineering methods allow the fabrication of polymeric resorbable scaffolds tailored for tissue engineering, targeted drug delivery, surgery, cardiology, aesthetics, dentistry, and cardiovascular care. Evaluating the internal architecture of these scaffolds using medical imaging modalities, such as cardiac computer tomography, offers vital clinical insights that assist in refining material properties to meet rigorous medical standards. In addition to technical fabrication and imaging assessments, the pathway toward translating these polymeric formulations from laboratory research into marketable clinical products involves navigating strict legal and regulatory frameworks, which present notable hurdles for successful deployment.
Bioresorbable materials break down naturally within the human body, removing the need for surgical removal. Refining how these materials are manufactured, evaluated by medical scans, and approved by regulators is essential for creating safer implants, advanced dental treatments, and targeted therapies for cardiovascular and surgical patients.
The work addresses applications across tissue engineering, drug delivery, surgery, aesthetics, dentistry, and cardiology. Target end users include medical device manufacturers, clinicians, and pharmaceutical developers. Because the work focuses on regulatory challenges and clinical translation alongside fabrication, these technologies range from applied research to devices navigating market clearance hurdles.
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Herein, the recent advances in the development of resorbable polymeric-based biomaterials, their geometrical forms, resorption mechanisms, and their capabilities in various biomedical applications are critically reviewed. A comprehensive discussion of the engineering approaches for the fabrication of polymeric resorbable scaffolds for tissue engineering, drug delivery, surgical, cardiological, aesthetical, dental and cardiovascular applications, are also explained. Furthermore, to understand the internal structures of resorbable scaffolds, representative studies of their evaluation by medical imaging techniques, e.g., cardiac computer tomography, are succinctly highlighted. This approach provides crucial clinical insights which help to improve the materials' suitable and viable characteristics for them to meet the highly restrictive medical requirements. Finally, the aspects of the legal regulations and the associated challenges in translating research into desirable clinical and marketable materials of polymeric-based formulations, are presented.
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DOI: 10.1002/adhm.202401674
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