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article · Frontiers in Medicine

Endometrial carcinoma in Kenya: clinical and biomarker profiles of 123 cases seen at two tertiary referral centers

2025Open accessMoi University

Abstract

This study provides a comprehensive clinicopathologic and immunophenotypic profile of EC in a Kenyan population. The predominance of endometrioid carcinoma and the frequent loss of MMR proteins in this subgroup align with global trends. However, the high proportion of p53-abnormal tumors, particularly among serous carcinomas, suggests a significant presence of biologically aggressive disease. These findings highlight the utility of IHC as a practical and informative tool for subtype classification and risk stratification in resource-limited settings.

Research topics

  • Endometrial and Cervical Cancer Treatments
  • Cervical Cancer and HPV Research
  • Cancer-related molecular mechanisms research

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DOI: 10.3389/fmed.2025.1607693

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