article · International Journal of Molecular Sciences
A new quick, simple, and sensitive voltammetric method has been developed for detecting paracetamol (PCT) in various samples. This method uses a carbon paste electrode modified with stevensite monoclinic clay mineral (Stv-CPE). The electrode's behaviour was characterised using techniques such as cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The research established a detection limit of 0.2 μM and a quantitation limit of 0.5 μM for PCT under optimal conditions. The method demonstrated a linear working concentration range of 0.6-100 μM. It was successfully applied to determine PCT content in complex matrices, including human serum and commercial solid pharmaceutical formulations, validating its effectiveness for quantitative analysis.
Accurate and timely detection of paracetamol is crucial because, while widely used, excessive intake can cause severe liver and kidney damage. This research offers a sensitive and straightforward method to monitor paracetamol levels in biological fluids and medicines, helping to prevent adverse health effects and ensure drug safety.
This research presents an early-stage analytical method for detecting paracetamol, which could be developed into a diagnostic tool or a quality control system. Potential users include clinical laboratories for monitoring patient drug levels and pharmaceutical manufacturers for ensuring the correct dosage in formulations. The method's simplicity and sensitivity suggest a pathway towards practical application in healthcare and industry.
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Paracetamol (PCT), or acetaminophen, is an important drug used worldwide for various clinical purposes. However, the excessive or indiscriminate use of PCT can provoke liver and kidney dysfunction; hence, it is essential to determine the amount of this target in biological samples. In this work, we develop a quick, simple, and sensitive voltammetric method using chemically modified electrodes to determine PCT in complex matrices, including human serum and commercial solid formulations. We modify the carbon paste electrode with stevensite monoclinic clay mineral (Stv-CPE), using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy to characterise and detect PCT. The kinetics study provides a better electrochemical characterisation of the electrode behaviour, finding the detection and quantitation limits of 0.2 μM and 0.5 μM under favourable conditions. Further, the best linear working concentration range is 0.6-100 μM for PCT, applying the proposed method to the quantitative determination of PCT content in reference tablet formulations and biological samples for validation.
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DOI: 10.3390/ijms241411269
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