Efficacy of topical nicotinamide gel in treatment of acne vulgaris

Abstract

Background: Acne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that primarily involves the face and trunk and affects approximately 9% of the population worldwide. While acne primarily affects adolescents, it can occur across various age groups. Acne can be classified by the age of onset: neonatal acne (under 4 weeks old), infantile acne (3–16 months old), mid-childhood acne (1–7 years old), prepubertal acne (7–9 years old), adolescent acne (10–18 years old), and adult acne (over 25 years old, either persisting from adolescence or appearing as new late-onset acne. The diagnosis of acne vulgaris primarily relies on clinical assessment. The aim of this study is to evaluate the efficacy and safety of topical nicotinamide gel in treatment of acne vulgaris, in order to improve its management. Methods: this study included 24 acne patients they were analyzed and photographed before and after treatment with nicotinamide. Results: Improvement percentage of inflammatory lesions before and after the treatment with Nicotinamide revealed that the lesions were reduced by (61.63 ± 21.19). Conclusion: Nicotinamide can be a beneficial adjunctive treatment for acne, particularly for individuals who may not tolerate more aggressive therapies.