EFFICACY OF COMBINATION OF ANTIBIOTICS IN TREATMENT OF INFECTED DECIDUOUS MOLARS

Abstract

Abstract Dental caries is a significant global health issue, often leading to pulp necrosis and infection in primary teeth. Traditional pulpectomy procedures face limitations due to complex root anatomy and patient cooperation, prompting the search for alternative treatments. This study compares the effectiveness of Lesion Sterilization and Tissue Repair (LSTR) using a modified 3Mixed-MP mortal pulpotomy (ciprofloxacin, metronidazole, amoxicillin in macrogol-propylene glycol) versus conventional formocresol for treating pulpitis and periapical lesions in primary molars. A split-mouth randomized clinical trial was conducted on fifteen children with bilateral non-vital mandibular primary molars. One molar received formocresol treatment while the opposing tooth was treated with the modified 3Mixed-MP mortal pulpotomy. Clinical parameters-pain, swelling, mobility-and radiographic measures of root length and bone density were evaluated at 1-, 3-, and 6-months post-treatment. Both therapies resulted in high clinical success and symptom resolution at 6 months. Formocresol offered slightly higher success rates for pain relief and bone density improvement (86.7%) compared to 3Mix-MP (60%), but both treatments preserved root integrity without marked resorption. The 3Mix-MP technique exhibited transient inflammatory signs, yet its minimally invasive nature and shorter procedure time make it advantageous for uncooperative pediatric patients. Survival analysis indicated longer-lasting benefits for formocresol. In summary, dual-antibiotic LSTR (3Mixed-MP) presents a viable, less traumatic option for managing infected primary molars. Further research is recommended to optimize antibiotic protocols and enhance long-term outcomes for pediatric endodontic care.