review · Diabetology & Metabolic Syndrome
Evidence gathered from clinical trials demonstrates that combining glucagon-like peptide-1 receptor agonists with lifestyle modifications provides a more effective approach for managing individuals with prediabetes than relying on lifestyle changes on their own. This combined intervention demonstrates a tolerable safety profile across evaluated patient groups. As a result of these findings, future clinical guidelines could benefit from incorporating these medications alongside standard behavioural adjustments. Adopting such combined treatment strategies offers the potential to achieve superior therapeutic management in prediabetic populations whilst also helping to improve overall patient adherence to treatment programmes.
Prediabetes increases the risk of developing full type 2 diabetes and related metabolic complications. Demonstrating that medical therapies can be safely paired with lifestyle interventions gives clinicians and healthcare providers an effective, well-tolerated strategy to improve patient care and support adherence before the condition progresses.
The findings support an applied clinical pathway where pharmaceutical developers and healthcare providers can position glucagon-like peptide-1 receptor agonists as adjunct therapies in prediabetes management protocols. Because the findings are based on a systematic review and meta-analysis of randomised controlled trials, the therapeutic approach represents tested, near-market clinical evidence suitable for informing healthcare guidelines and medical practice.
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GLP-1RAs combined with lifestyle modification proved to be a more effective therapy for managing prediabetic patients than lifestyle modification alone, with a tolerable safety profile. Future guidelines should consider GLP-1RAs as an adjunct to lifestyle modification in the management of prediabetic patients to provide better management and improve treatment adherence.
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DOI: 10.1186/s13098-024-01371-3
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