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article · Baylor University Medical Center Proceedings

Efficacy and safety of fezolinetant for vasomotor symptoms in postmenopausal women: a comprehensive systematic review and meta-analysis of randomized controlled trials

20251 citationAlexandria University

Abstract

Fezolinetant effectively reduces VMS in postmenopausal women at both 4 and 12 weeks, aligning with previous research. It also improves quality of life, with a promising safety profile. Given fezolinetant's potential for liver enzyme elevations, it is essential to monitor liver function at baseline and regularly thereafter (monthly for the first 3 months and at 6 and 9 months) to ensure patient safety. Further studies with larger sample sizes are needed to confirm these findings.

Research topics

  • Menopause: Health Impacts and Treatments
  • Estrogen and related hormone effects
  • Menstrual Health and Disorders

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DOI: 10.1080/08998280.2025.2491894

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