article · Journal of Animal Physiology and Animal Nutrition
This research examined how adding prebiotics or probiotics to broiler feed influences the pharmacokinetics of the antibiotic florfenicol. Two hundred 35-day-old broiler chickens were divided into four equal groups. One group received a single intravenous dose of florfenicol to establish bioavailability, while a second received the drug orally for five consecutive days without additives. The remaining two groups received oral florfenicol for five days followed by ten days of dietary prebiotic or probiotic supplementation. Blood concentrations were assessed using high-pressure liquid chromatography, alongside residue levels in liver, kidney, and muscle tissues. Birds receiving prebiotics or probiotics demonstrated significantly higher maximum concentration and area under the curve values for florfenicol, alongside marked reductions in drug clearance and apparent volume of distribution. Dietary additives also altered cumulative drug levels in liver and kidney tissues.
Understanding how standard feed additives interact with veterinary medicines is essential for poultry management. Because prebiotics and probiotics alter how florfenicol is cleared and where it accumulates, these findings highlight the need to account for feed composition when calculating therapeutic antibiotic doses and assessing drug residues in edible organs such as the liver and kidney.
This research informs poultry producers and veterinary medicine developers seeking to optimise antibiotic regimens alongside functional feed additives. As an applied in vivo study demonstrating pharmacokinetic shifts and tissue accumulation, the work represents early-stage testing. Additional trials assessing formal withdrawal times and commercial flock performance are necessary before these findings can directly alter on-farm feeding and treatment guidelines.
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We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in broilers feed. Unsexed two hundred, thirty-five-day-old broiler chickens, were put in four equal groups (n = 50). The first group was administrated florfenicol intravenous at 30 mg/kg body weight (BW) only once dosage without pre- or probiotic administration to determine the bioavailability. While, the second group was administrated florfenicol (intracrop routes; a dosage of 30 mg/kg BW for five progressive days) without pre- or probiotic co-administration. The third and the fourth groups were administrated the same dose of florfenicol (intracrop route) for five successive days, followed by 10 days of prebiotic or probiotic treatment respectively. The plasma florfenicol % was identified by high-pressure liquid chromatography (HPLC) after the first florfenicol administration (intravenous or intracrop routes) in all groups. Then, the residual levels of florfenicol were determined in liver, kidney and muscle tissues from the second, third and fourth groups which were exposed to florfenicol orally. Our results demonstrated that broilers pre-treated with prebiotic or probiotic significantly increased C<sub>max</sub> , AUC<sub>0-</sub> <sub>t</sub> , AUC<sub>0-inf</sub> as well as AUMC values, while significant drop was recorded in V/F and CL/F. Prebiotic or probiotic influenced the cumulative effect of florfenicol in liver and kidney tissues of treated birds.
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DOI: 10.1111/jpn.13317
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