article · ACS Omega
This research evaluates the use of mesoporous silica nanospheres as an adsorbent material for removing doxorubicin, a pharmaceutical compound, from aqueous solutions. The structural and surface characteristics of the nanospheres were examined using standard physical and chemical characterisation techniques. Using a Box-Behnken statistical design and response surface modelling, the conditions for optimal doxorubicin uptake were identified, achieving an adsorption capacity of 804.84 milligrams per gram. This performance was attained at a neutral-to-slightly-acidic pH of 6, an adsorbent dosage of 0.02 grams per 25 millilitres, a shaking speed of 200 revolutions per minute, and a contact time of 100 minutes. The adsorption process was found to be spontaneous and endothermic, with higher temperatures improving removal. The nanospheres retained their functional capacity across five recycling cycles with only modest performance loss.
Pharmaceutical residues like doxorubicin pose environmental concerns when released into water systems. Identifying robust, high-capacity materials that can capture these compounds and be reused multiple times helps advance methods for treating contaminated water, potentially reducing the ecological footprint of healthcare and pharmaceutical effluents.
This work represents early-stage, laboratory-tested research that could interest water treatment facilities and pharmaceutical waste management operators seeking reusable adsorbents for drug removal. While the material demonstrates a high adsorption capacity and can be recycled five times at bench scale, the abstract does not indicate testing on actual industrial wastewater or outline a pathway toward pilot-scale manufacture.
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The aim of this study is to evaluate the efficacy of mesoporous silica nanospheres as an adsorbent to remove doxorubicin (DOX) from aqueous solution. The surface and structural properties of mesoporous silica nanospheres were investigated using BET, SEM, XRD, TEM, ζ potential, and point of zero charge analysis. To optimize DOX removal from aqueous solution, a Box-Behnken surface statistical design (BBD) with four times factors, four levels, and response surface modeling (RSM) was used. A high amount of adsorptivity from DOX (804.84 mg/g) was successfully done under the following conditions: mesoporous silica nanospheres dose = 0.02 g/25 mL; pH = 6; shaking speed = 200 rpm; and adsorption time = 100 min. The study of isotherms demonstrated how well the Langmuir equation and the experimental data matched. According to thermodynamic characteristics, the adsorption of DOX on mesoporous silica nanospheres was endothermic and spontaneous. The increase in solution temperature also aided in the removal of DOX. The kinetic study showed that the model suited the pseudo-second-order. The suggested adsorption method could recycle mesoporous silica nanospheres five times, with a modest reduction in its ability for adsorption. The most important feature of our adsorbent is that it can be recycled five times without losing its efficiency.
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DOI: 10.1021/acsomega.3c00829
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