Effect of two doses of coenzyme Q10 on spermogram parameters, sperm chromatin integrity and partner pregnancy rate in men with idiopathic oligoasthenozoospermia: A prospective study

Abstract

Objective: To evaluate the effectiveness of two doses of coenzyme Q10 (CoQ10) on semen parameters, sperm DNA damage, and the partner pregnancy rate in men with idiopathic oligoasthenozoospermia. Methods: 250 patients with idiopathic oligoasthenozoospermia were examined. The first group ( n =125) received 100 mg/day of CoQ10 and the second group ( n =125) received 200 mg/day of CoQ10 orally for 6 months. Semen parameters, DNA fragmentation index (DFI) and the partner pregnancy rate were analyzed at baseline and after 6 months of treatment. Results: Comparing with baseline data, treatment with CoQ10 (100 mg/day or 200 mg/day) resulted in a significant increase in sperm concentration (both P <0.001), a significant improvement in progressive motility and total motile sperm count ( P =0.05, P =0.001, respectively). The mean DFT was significantly improved after treatment with CoQ10 at 100 mg/day and at 200 mg/day, after 6 months of treatment ( P <0.01). Moreover, CoQ10 significantly improved the partner pregnancy rate. A strongest correlation was found between seminal fluid parameters and DFI ( P <0.001). Conclusions: CoQ10 is effective in improving semen parameters, DFI and on the partner pregnancy rate after 6 months with CoQ10 at two doses, with a greater improvement shown in men who took 200 mg/day than in those who took 100 mg/day.