Effect of Moringa oleifera on some physiological parameters in diclofenac treated rats

Abstract

The present work aims to study the potential effect of aqueous leaves extract Moringaoleifera (MO) on male albino rats treated orally with diclofenac sodium (DcNa). Fortyfive male albino rats were used and randomly divided into 5 groups as follows: group I"normal group", group II "DcNa group", group III "MO group", group IV "DcNa thenMO group" and group V "MO then DcNa group". Treatment with DcNa showed asignificant decrease in body weight while caused significant increases in relative organsweight (liver, kidney, spleen and brain). Moringa oleifera caused a significant increasein body weight while showed non-significant decreases in relative organs weight (liver,kidney and spleen). DcNa exhibited significant decreases in WBCs count, lymphocytes% and neutrophil % while caused a significant increase in monocyte %. Also, there werenon-significant increase and decrease in eosinophil % and basophil % respectively.Treatment with MO showed non-significant increases in white blood cell count,monocyte % and neutrophil % while showed non-significant decrease in lymphocyte %.Eosinophil % and basophil % were increased significantly. Administration of DcNacaused significant decreases in serum total protein, albumin and globulin levels.Treatment with Moringa oleifera showed a significant increase in serum albumin levelwhile showed non-significant increases in serum total protein and globulin levels.The present study suggests that Moringa oleifera is useful in maintaining the harmfuleffect of diclofenac sodium in male albino rats.