article · PubMed

Effect of Aromatase Inhibitor Letrozole on the Placenta of Adult Albino Rats: A Histopathological, Immunohistochemical, and Biochemical Study.

Mohamed Ali Alabiad
Ibtesam Elhasadi
Walaa Samy
Amany Mohamed Shalaby
Sulaiman Mohammed Alnasser
Ahmed Ismail Heraiz
Mohammed Alorini
Fatima A. Jaber
Ahmed Baker A. Alshaikh
Khalid Mohammed Mohammed Albakoush
Dina Ahmed Khairy

20243 citationsOpen accessZagazig University

Abstract

Letrozole inhibited the expression of ER and PR in rat placenta. It interrupted stimulatory vascular signals causing significant apoptosis and placental vascular dysfunction. Letrozole in an equivalent human daily dose of 10 mg caused a high post-implantation loss rate without imposing severe side effects.

Research topics

Reproductive System and Pregnancy
Pregnancy and preeclampsia studies
Cancer Risks and Factors

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.30476/ijms.2023.96905.2853

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